ECM Remodeling in Fibrotic Diseases

Pathophysiological Roles of Extracellular Matrix Remodeling in Obesity-related Metabolic Diseases

  • ECM Remodeling in obesity and cancer
  • Trends in Cell Biology (2022)_Published by Park’s Lab
TCB-figure1
  • Fibro-inflammation
  • Angiogenesis
  • ER stress
  • Hypoxic stress
Research-3-1

Extracellular Matrix Protein Remodeling in Adipose tissues

  • Type 6 Collagen (Col6)-derived endotrophin (ETP) in fibrotic diseases
  • High levels of ETP in adipose tissues of obese insulin resistant patients compared to that in obese insulin sensitive subjects (2014, Nature Communications)
Research-3-2

Extracellular Matrix Protein Remodeling in Liver Tissues (NASH and HCC)

  • High levels of ETP in non-tumoral liver tissues of HCC are tightly correlated with poor out comes
  • ETP mediates reciprocal interactions among the various types of hepatic cells during chronic liver diseases (2018, Journal of Pathology)
Research-3-2_00002