Publication

2024

  • Lee B, Rho JS, Jeong H, Kim Y, Lee J, Yun C, Park J, Kim, D-S, Lee J, So MK, Kim A, Aohn DH*, and Lee S-G*. Ginkgo biloba extract ameliorates skin fibrosis in a bleomycin-induced mouse model of systemic sclerosis. Animal Cells and Systems.  2024.12. (28)152-160  Paper link
  • Jeon YG, Nahmgoong H, Oh J, Lee D, Kim DW, Kim JE, Kim YY, Ji Y, Han JS, Kim SM, Shon JH, Lee WT, Kim SW, Huh JY, Jo K, Cho J, Park J and Kim, JB. Ubiquitin ligase RNF20 coordinates sequential adipose thermogenesis with brown and beige fat-specific substrates. Nature Communications  (IF: 16.6) 2024.01. (15)940  Paper link
  • Kim S, Oh J, Park C, Kim M, Jo W, Kim C-S, Cho SW and Park J*. FAM3C in cancer-associated adipocytes promotes breast cancer cell survival and metastasis. Cancer Research  (IF: 12. 5) 2024.01. 84 (4): 545–559  Paper link
Fam3c-Model

2023

  • Han SM, park ES, Park J, Nahmgoong H, Choi YH, Oh J, Yim KM, Lee WT, Lee YK, Jeon YG, Shin KC, Huh JY, Choi SH, Park J, Kim JK, and Kim, JB. Unique adipose tissue invariant natural killer T cell subpopulations control adipocyte turnover in mice. Nature Communications  (IF: 16.6) 2023.12. (14)8512  Paper link
2023-NC-figure
  • Oh J, Park C, Kim S, Kim M, Kim C-S,  Jo W, Park S, Yi G-S, and Park J*. High levels of intracellular endotrophin in adipocytes mediate COPII vesicle supplies to autophagosome to impair autophagic flux and contribute to systemic insulin resistance in obesity. Metabolism-Clinical and Experimental (IF: 13. 934, JCR 4.8 %) 2023.06.  Volume 145, 155629  Paper link
20230614_104942-abstract
  • Lee C, Kim M, Park C, Jo W, Seo JK, Kim S, Oh J, Kim C-S, Ryu HS, Lee K-H and Park J*. Epigenetic regulation of Neuregulin 1 promotes breast cancer progression associated to hyperglycemia. Nature Communications  (IF: 17. 694) 2023.02.  14(1) 439  Paper link
KakaoTalk_20230502_202000240
  • Choi C#, Kim H#, Oh J, Park C, Kim M, Kim C-S and Park J*. DSCR1 deficiency ameliorates the Aβ pathology of Alzheimer’s disease by enhancing microglial activity. Life Science Alliance  (IF: 5.781) 2022.11.  (6)e202201556 #co-first authors  Paper link
20230614_142948_fig3

2022

  • Kim M#*, Lee C#, and Park J*. Extracellular matrix remodeling facilitates obesity-associated cancer progression. Trends in Cell Biology  (IF: 20.808) 2022.10. 32(10)825-834 #co-first authors  Paper link
TCB-figure1
  • Jo W, Kim M, Oh J, Kim C-S, Park C, Yoon S, Lee C, Kim S, Nam D, Park J*. MicroRNA-29 ameliorates fibro-inflammation and insulin resistance in HIF1α-deficient obese adipose tissue by inhibiting endotrophin generation.  Diabetes (IF: 9.461) 2022.08. 71(8)1746-1762 Paper link
Model
  • Park J, Lee D, Ham S, Oh J, Noh J, Lee Y, Park Y, Lee G, Han S, Han J, Kim Y, Jeon Y, Han N,  Shin K, Kim S, Choi S, Lee C, Park J, Roh T, S Kim & Kim J. Targeted erasure of DNA methylation by TET3 drives adipogenic reprogramming and differentiation. Nature Metabolism. 4(7)918-931. (IF:19.865)
  • Zhu Q, Zhu Y, Hepler C, Zhang Q, Park J, Gliniak C, Henry GH, Crewe C, Bu D, Zhang Z, Zhao S, Morley T, Li N, Kim DS, Strand D, Deng Y, Robino JJ, Varlamov O, Gordillo R, Kolonin MG, Kusminski CM, Gupta RK, Scherer PE. Adipocyte mesenchymal transition contributes to mammary tumor progression. Cell Reports.  40(11)111362 (IF:9.995)

2021

  • Lee YH, Jang HJ, Kim S, Choi SS, Kim KW, Eom HJ, Hyun J, Shin KJ, Chae YC, Kim H, Park J, Park NH, Woo CY, Hong CH, Koh EH, Nam D*, and Choi JH*. Hepatic MIR20B promotes nonalcoholic fatty liver disease by suppressing PPARA.  eLife (IF:8.146) 2021.12., (10)e70472 

 

  • Choi C, Park J, Kim H, Chang KT, Park J*, Min KT. DSCR1 upregulation enhances dural meningeal lymphatic drainage to attenuate amyloid pathology of Alzheimer’s disease. Journal of Pathology. (IF: 9.883, JCR 4.5%) 2021.11. (255)3, *Corresponding author,  Paper Link  

 

  • Hyun J, Park MH, Lee YH, Lee Y, Choi SS, Kim KW, Eom HJ, Hur J, Park CY, Kim J, Park J, Ryu HW, Jang H, Oh S, Choi JH. Vernicia fordii (Hemsl.) Airy Shaw extract stimulates insulin secretion in pancreatic β-cells and improves insulin sensitivity in diabetic mice.  Journal of Ethnopharmacology. (IF:4.36) 2021.10., 114238  Paper Link 
  • Oh J, Kim C, Kim M,  Jo W, Sung YH, and Park J*.  Type VI collagen and its cleavage product, endotrophin, cooperatively regulate the adipogenic and lipolytic capacity of adipocytes. Metabolism-Clinical and Experimental. (IF:13.934, JCR 4.5%) 2021.01., 114:154430  Paper Link
Model

2020

  • Kim M, Lee C, Seo DY, Horton J.D, Lee HJ, Park J*, and Scherer P.E*. The Impact of Endotrophin on the Progression of Chronic Liver Disease.  Experimental & Molecular Medicine. (IF: 15.153, JCR 6.9%) 2020.10., 52:1766-1776, *Co-corresponding authors  Paper Link 
20230510_123941
  • Lee C#, Ryu HW#, Kim S, Oh S, Ahn K, and Park J*. Verminoside from Pseudolysimachion rotundum var. subintegrum sensitizes cisplatin-resistant cancer cells and suppresses metastatic growth of human breast cancer. #Equal contribution. Scientific Reports. (IF:4.996) 2020.10., 10:20337  Paper Link
Model_00000
  • Lee JM, Choi SS, Park MH, Jang H, Lee YH, Khim KW, Oh SY, Park J, Ryu HW, and Choi JH. Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK Activation. Nutrients. (IF:5.717) 2020.03., 12(3) 

 

  • Park J, Huh JY, Oh J, Kim JI, Han SM, Shin KC, Jeon YG, Choe SS, Park J, and Kim JB. Activation of invariant natural killer T cells stimulates adipose tissue remodeling via adipocyte death and birth in obesity. Genes & Development. (IF:11.361) 2019.12., 33(23-24)1657-1672

2019

  • Lee HH, An SM, Ye BJ, Lee JH, Yoo EJ, Jeong GW, Kang HJ, Alfadda AA, Lim SW, Park J, Lee-Kwon W, Kim JB, Choi SY, and Kwon HM. TonEBP/NFAT5 promotes obesity and insulin resistance by epigenetic suppression of white adipose tissue beiging. Nature Communications 2019.08. (10)3536

 

  • Bu D, Crewe C, Kusminski CM, Gordillo R, Ghaben AL, Kim M, Park J, Deng H, Xiong W, Liu XZ, Lonning PE, Halberg N, Rios A, Chang Y, Gonzalez A, Zhang N, An Z and Scherer PE. Human endotrophin as a driver of malignant tumor growth. JCI Insight. 2019.05. 4(9)e125094

 

  • Yoon S, Nguyen HCT, Jo W, Kim J, Chi SM, Park J, Kim SY and Nam D. Biclustering analysis of transcriptome big data identifies condition-specific microRNA targets. Nucleic Acid Research. 2019.05. 47(9)e53

 

  • Lee A, Jo S, Lee C, Shin HH, Kim TH, Ahn KJ, Park SK, Cho H, Yoon HK, Kim WG, Park J* and Choi Y*. Diabetes as a prognostic factor in HER-2 positive breast cancer patients treated with targeted therapy. Breast Cancer. 2019.03. 26(5)672-680. Corresponding authors*

 

  • Alfadda AA, Sallam RM and Park J. Diet and nutrition for body weight management. Journal of Obesity. 2019.03;  2019, Article ID 6798096.

 

  • Lee C, Kim M, Lee JH, Oh J, Shin H, Lee SM, Scherer PE, Kwon HM, Choi JH, Park J*. COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease. Journal of Pathology (IF: 9.883, JCR 4.5%). 2019.01; 247(1)99-109

 

  • Lee JH, Suh JH, Choi SY, Kang HJ, Lee HH, Ye BJ, Lee GR, Jung SM, Kim CJ, Lee-Kwon W, Park J, Myung K, Park NH, Kwon HM.  Tonicity-responsive enhancer-binding protein promotes hepatocellular carcinogenesis, recurrence and metastasis.  Gut. 2019.02; 68(2)347-358

2017

  • Park J, Kim M, Sun K, An YA, Gu X and Scherer, P.E.  VEGF-A expressing adipose tissue shows rapid beiging, enhanced survival after transplantation and confers IL4-independent metabolic improvements. Diabetes. 2017 June; 66(6) 1479-1490

 

  • Sun K#, Park J#, Kim M# and Scherer, P.E. Endotrophin, a multifaceted player in metabolic dysregulation and cancer progression, is a predictive biomarker for the response to PPARg agonist treatment.  Diabetologia. 2017 Jan; 60(1) 24-29. #Equal contribution

 

2016

  • Lee C, An D, and Park J*. Hyperglycemic memory in metabolism and cancer. Hormone Molecular Biology and Clinical Investigation 2016 May; DOI:10.1515/hmbci-2016-0022

 

  • Choi S, Kim ES, Jung JE, Marciano DP, Jo A, Koo JY, Choi SY, Yang YR, Jang HJ, Kim EK, Park J, Kwon HM, Lee IH, Park SB, Myung KJ, Suh PG, Griffin PR, Choi JH. PPARγ antagonist Gleevec improves insulin sensitivity and promotes the browning of white adipose tissue. Diabetes. 2016; 65(4) 829-839

2015

  • Choi S, Jung J, Yang YR, Kim E, Jang H, Kim E, Kim IS, Lee J, Kim J, Seo JK, Kim J, Park J, Suh PG, Choi JH. (2015) Novel phosphorylation of PPARγ ameliorates obesity-induced adipose tissue inflammation and improves insulin sensitivity. Cellular Signaling. 2015; 27:2488-2495

2014

  • Ryu TY, Park J* and Scherer P.E* (2014) Hyperglycemia as a risk factor for cancer progression. Diabetes & Metabolism Journal. 2014; 38:330-336 *corresponding authors

 

  • Choi S, Park J and Choi J.H (2014) Revisiting PPARg as a target for the treatment of metabolic disorders. BMB Reports. 2014; 47: 599-608

 

  • Park J, Morely S.T, Kim M, Clegg D and Scherer P.E (2014) Obesity and Cancer: mechanisms underlying tumour progression and recurrence. Nature Reviews Endocrinology. 2014. Aug. (10)455-465. Doi:10.1038/nrendo.2014.94

 

  • Kim M, Neinast M, Frank A, Sun K, Park J, Zehr J, Vishvanath L, Morselli E, Amelotte M, Palmer B, Gupta R, Scherer P.E and Clegg D. (2014) ERα upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue. Molecular Metabolism. 2014 Jun 7; 3(6):642-51.

 

  • Kusminski C.M, Park J and Scherer P.E. (2014) MitoNEET-Mediated Effects on Browning of White Adipose Tissue. Nature Communications. 2014. May. (5)3962. Doi: 10.1038/ncomms4962

 

  • Sun K#, Park J#, Gupta O, Holland W.L, Auerbach P.L, Zhang N, Marangoni R.G, Nicoloro S.M, Czech M.P, Varga J, Ploug T, An Z and Scherer P.E. (2014) Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction. Nature Communications. 2014. March. (5) 3485. doi:10.1038/ncomms4485 # Equal contribution

 

  • Lackey DE, Burk DH, Ali MR, Mostaedi R, Smith WH, Park J, Scherer PE, Seay SA, McCoin CS, Bonaldo P, Adams SH. (2014) Contributions of adipose tissue architectural and tensile properties toward defining healthy and unhealthy obesity. Am J Physiol Endocrinol Metab. 2014 Feb. 306(3)E233-46

2013

  • Park J, Morely T. S, and Scherer P.E. (2013) Inhibition of Endotrophin, a Cleavage Product of Collagen VI, Confers Cisplatin Sensitivity to Tumors. EMBO Molecular Medicine 2013 Jun;5(6):935-48

 

  • Ham M, Lee J, Choi A.H, Jang H, Choi G, Park J, Kozuka C, Masuzaki H, and Kim JB. (2013) Macrophage glucose-6-phosphate dehydrogenase stimulates proinflammatory responses with oxidative stress. Molecular Cellular Biology 2013 Jun;33(12):2425-35

 

  • Park J, and Scherer P.E. (2013) Endotrophin in the tumor stroma: a new therapeutic target for breast cancer? Expert Review of Anticancer Therapy. 13(2):111-113

2012

  • Park J. and Scherer P.E. (2012) Endotrophin – a Novel Factor Linking Obesity with Aggressive Tumor Growth. Oncotarget. 3(12):1487-8

 

  • Park J, Sarode V, Euhus D, Kittler R, and Scherer P.E. (2012) The Neuregulin 1-HER Axis as a Key Mediator of Hyperglycemic Memory Effects in Breast Cancer. Epub 2012 Dec 3 Proc. Natl. Acad. Sci. USA.109(51):21058-63

 

  • Park J, and Scherer P. E. (2012) Adipocyte-derived endotrophin promotes malignant tumor progression. Journal of Clinical Investigation. 2012 Nov 1;122(11):4243-56. Epub 2012 Oct
    • Featured in the JCI Scientific Show Stoppers
    • Highlighted in the Research Highlights in Nature Reviews Cancer 12(11):p737(doi:10.1038/nrc3392) Nov. 2012
    • Highlighted in the Cover Story in Science-Business eXchange. Nature publishing group. Oct. 18. 2012 (doi: 10.1038/scibx.2012.1071)
    • Highlighted in the News in Cancer Discovery. Oct. 18. 2012 (doi. 10.1158/2159-8290.CD-RW2012-179)

 

  • Kusminski C.K, Holland W. L, Sun K, Park J, Spurgin S, Lin Y, Askew R, Simcox J. A, McClain D.A, Li C and Scherer P.E. (2012) MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity. Nature Medicine.2012 Sep 9; 18(10):1539-49. Doi:10.1038/nm.2899. Epub 2012 Sep 9.
    • Highlighted in the cover image. Cover image credit: David Gresham, Christine Kusminski, William Holland and Jiyoung Park. Cover designL Matt Hansen

2011

  • Park J, and Scherer P.E. (2011) Leptin and Cancer: From Cancer Stem Cells to Metastasis. Endocrine-Related Cancer.Jul 11;18(4):C25-9.

 

  • Park J, Euhus D.M., Scherer P.E. (2011) Paracrine and Endocrine Effects of Adipose tissue on Cancer Development and Progression. Endocrine Reviews.32(4):550-70. Epub 2011 Jun 2

 

  • Lee JW, Choi AH, Ham M, Kim JW, Choe SS, Park J, Lee GY, Yoon KH, Kim JB. (2011) G6PD Up-Regulation Promotes Pancreatic {beta}-Cell Dysfunction. Endocrinology. 2011 Mar;152(3):793-803. Epub 2011 Jan 19

2010

  • Park J, Kusminski C.M., Chua S. C. and Scherer P.E. (2010) Leptin receptor signaling supports cancer cell metabolism through suppression of mitochondrial respiration in vivo. American Journal of Pathology, 2010 Dec;177(6):3133-44. Epub 2010 Nov 5.

 

  • Landskroner-Eiger S, Park J, Israel D, Pollard JW, Scherer PE. (2010) Morphogenesis of the developing mammary gland: stage-dependent impact of adipocytes. Developmental Biology. 2010 Aug 15;344(2):968-78.

before 2009

  • Shin ES, Park J, Shin JM, Cho D, Cho SY, Shin DW, Ham M, Kim JB, Lee TR. (2008) Catechingallates are NADP+-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme. Bioorganic & Medicinal Chemistry. 2008 Apr; 16(7):3580-3586.

 

  • Park J, Chung J and Kim JB (2007) New Insights of Redox Regulating System in Adipose Tissue of Obesity. Diabetes Research and Clinical Practice.2007 Sep;77Suppl 1:S11-6. Epub 2007 Apr 23.

 

  • Choe SS, Choi AH, Lee JW, Kim KH, Chung JJ, Park J, Lee KM, Park KG, Lee IK, Kim JB (2007) Chronic Activation of Liver X Receptor Induces b-cell Apoptosis through Hyperactivation of Lipogenesis. Diabetes. 2007 Jun;56(6):1534-43. Epub 2007 Mar 16

 

  • Park J, Choe SS, Choi AH, Kim KH, Yoon MJ, Suganami T, Ogawa Y, Kim JB (2006) Increase in Glucose-6-Phosphate Dehydrogenase in Adipocytes Stimulates Oxidative Stress and Inflammatory Signal. Diabetes.2006. Nov; 55(11): 2939-2949

 

  • Park J, Rho HK, Kim KH, Choe SS, Lee YS, Kim JB (2005) Overexpression of Glucose-6-Phosphate Dehydrogenase is Associated with Lipid Dysregulation and Insulin Resistance in Obesity. Mol. Cell. Biol. 2005. Jun; 25(12): 5146-5157

 

  • Rho HK, Park J, Suh JH, Kim JB. (2005) Transcriptional regulation of mouse 6-phosphogluconate dehydrogenase by ADD1/SREBP1c. Biochem. Biophys. Res. Commun.2005. Jun; 332(1):288-296

 

  • Cho HJ, Park J, Lee HW, Lee YS, Kim JB. (2004) Regulation of adipocyte differentiation and insulin action with rapamycin. Biochem. Biophys. Res. Commun. 2004. Sep; 321(4):942-948

 

  • Zhao C, Chen Y, Park J, Kim JB, Tang H. (2004) Tat-dependent repression of human immunodeficiency virus type 1 long terminal repeat promoter activity by fusion of cellular transcription factors. Biochem. Biophys. Res. Commun.2004. Sep; 322(2):614-622

 

  • Seo JB, Moon HM, Noh MJ, Lee YS, Jeong HW, Yoo EJ, Kim WS, Park J, Youn BS, Kim JW, Park SD, Kim JB. (2004) Adipocyte determination- and differentiation-dependent factor 1/sterol regulatory element-binding protein 1c regulates mouse adiponectin expression. J. Biol. Chem.2004. May; 279(21):22108-22117

 

  • Lee YS, Lee HH, Park J, Yoo EJ, Glackin CA, Choi YI, Jeon SH, Seong RH, Park SD, Kim JB. (2003) Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c. Nucleic Acids Res. 2003. Dec; 31(24):7165-7174

 

  • Seo JB, Noh MJ, Yoo EJ, Park SY, Park J, Lee IK, Park SD, Kim JB. (2003) Functional characterization of the human resistin promoter with adipocyte determination- and differentiation-dependent factor 1/sterol regulatory element binding protein 1c and CCAAT enhancer binding protein-alpha. Mol. Endocrinol.2003. Aug; 17(8):1522-1533

 

  • Park J. and Kim JB. (2002) Molecular Insights into Fat Cell Differentiation and Functional Roles of Adipocytokines. Kor. J. Endocrinology. 17: 1-9

 

  • Kim M, Lee W, Park J, Kim JB, Jang YK, Seong RH, Choe SY, Park SD. (2000) The stress-activated MAP kinase Sty1/Spc1 and a 3′-regulatory element mediate UV-induced expression of the uvi15(+) gene at the post-transcriptional level. Nucleic Acids Res.2000. Sep; 28(17):3392-3402