Communication between Adipocytes and Cancer Cells.
Obesity induced dysfunction of adipose tissue contibutes to cancer cell progression. (Nature Reviews (2014) Park, Jiyoung., et.al.)
The growing field of obesity in cancer biology over the last several years encompasses certain types of tumours, covering renal, oesophagus, gastrointestinal track and reproductive organs in both men and women. The increase in the risk of cancers in the obese population has focused more attention on the underling mechanisms rationalizing the connection of obesity and cancer aetiology.SCROLL_TEXT
This ranges from initiation to progression, and eventually to the drug development tailored to obese cancer patients. However, the mechanistic association between obesity and cancer still remain elusive.SCROLL_TEXT
Prof. Jiyoung Park’s laboratory endeavors multiple, interdisiplinary approaches ranging from molecular biology, biochemistry, and animal pathophysiology studies to uncover the molecular mechanisms how cancer cells communicate with tumor-stromal adipocytes.