ECM Remodeling and Fibrotic Diseases

Pathophysiological Roles of Extracellular Matrix Remodeling in Obesity-related Metabolic Diseases

Research-3-1

Research Area

  • Inflammation

  • Fibrosis

  • Angiogenesis

  • ER stress

  • Hypoxic stress

Research-3-2
  • Extracellular Matrix Protein Remodeling in Adipose tissues

  • Type 6 Collagen (Col6)-derived endotrophin (ETP) in fibrotic diseases

  • High levels of ETP in adipose tissues of obese insulin resistant patients compared to that in obese insulin sensitive subjects (2014, Nature Communications)

Research-3-2_00002
  • Extracellular Matrix Protein Remodeling in Liver Tissues

  • High levels of ETP in non-tumoral liver tissues of HCC are tightly correlated with poor out comes

  • ETP mediates reciprocal interactions among the various types of hepatic cells during chronic liver diseases (2018, Journal of Pathology)